The monophasic action potential upstrokea means of characterizing local conduction
作者:
JOSEPH,
LEVINE E.,
MOORE ALAN,
KADISH THOMAS,
GUARNIERI JOSEPH,
期刊:
Circulation
(OVID Available online 1986)
卷期:
Volume 74,
issue 5
页码: 1147-1155
ISSN:0009-7322
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
The upstrokes of monophasic action potentials (MAPs) recorded with an extracellular pressure electrode were characterized in isolated canine tissue preparations in vitro. The characteristics of the MAP upstroke were compared with those of the local action potential foot as well as with the characteristics of approaching electrical activation during uniform and asynchronous conduction. The upstroke of the MAP was exponential during uniform conduction. The time constant of rise of the MAP upstroke (TMAP) correlated with that of the action potential foot (Tf,o0): TMAP + 1.01 TfO,t + 0.50; r2 = .80. Furthermore, changes in Tf0Ot with alterations in cycle length were associated with similar changes in TMAP: Tfoot = 1.06 TMAP − 0. 1 1; r2 = .78. In addition, TMAP and Tfootboth deviated from exponential during asynchronous activation; the inflections that developed in the MAP upstroke correlated in time with intracellular action potential upstrokes that were asynchronous in onset in these tissues. Finally, the field of view of the MAP was determined and was found to be dependent in part on tissue architecture and the space constant. Specifically, the field of view of the MAP was found to be greater parallel compared with transverse to fiber orientation (6.02 + 1.74 vs 3.03 + 1.10 mm; p < .01). These data suggest that the MAP upstroke may be used to define and characterize local electrical activation. The relatively large field of view of the MAP suggests that this technique may be a sensitive means to record focal membrane phenomena in vivo.
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