AimTo investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.MethodA double-blind, placebo-controlled crossover study of 30 adult subjects.ResultsMean pain scores fell from a baseline of 8.12–7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P< 0.05). Side effects were minor.ConclusionThe CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.