The role of the ventromedial nucleus of the hypothalamus in epileptogenesis
作者:
Russell Ferland,
Craig Applegate,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 16
页码: 3623-3629
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Brain stem seizure;Epileptogenesis;Flurothyl;Forebrain seizure;Mice;Propagation;Ventromedial nucleus of the hypothalamus
数据来源: OVID
摘要:
FLUROTHYL kindling initiates a time-dependent process that results in a facilitated propagation from the fore-brain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating this facilitated propagation between these seizure systems. Bilateral ibotenic acid lesions of the VMH, but not the dorsomedial nucleus of the hypothalamus (DMH), resulted in a disruption in the propagation of seizure activity from the forebrain to the brainstem. Moreover, VMH lesioned mice were able to express brainstem seizures following minimal corneal electroconvulsive shock (mECS). Together, our results indicate that the VMH is a critical substrate involved in propagating seizure activity between the forebrain and brainstem, but is not involved in the expression systems necessary for forebrain or brainstem seizure manifestations.
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