Ultrastructural Morphometric Study of Follicular Center Lymphocytes: II. Analyses of Cleaved-Cell Populations Do Not Support the Lukes-Collins' Concept
作者:
DardickIrving,
CavellSharon,
MoherDavid,
SeelyPeggy,
DardickAlexander,
McDougallMarilyn,
BurnsBruce F.,
期刊:
Ultrastructural Pathology
(Taylor Available online 1989)
卷期:
Volume 13,
issue 4
页码: 393-404
ISSN:0191-3123
年代: 1989
DOI:10.3109/01913128909048490
出版商: Taylor&Francis
关键词: electron microscopy;morphometry;lymphocyte;nucleus
数据来源: Taylor
摘要:
Ultrastructural morphometric analysis was carried out on six cases of lymph node biopsies with reactive hyperplasia to establish the frequency and depth of invaginations in nuclear profiles situated in the mantle zones and follicular centers. The frequency distribution of the depth of invaginations was similar in nuclear profiles whether in the small lymphocytes of mantle zones or the small, partially transformed (centrocytes) and fully transformed (centroblasts) lymphocytes of follicular centers. Invaginated and cleaved lymphocytes were not confined to the partially transformed (centrocytic) lymphocytes of follicular centers, and nuclear profiles with invaginations bore no resemblance to those depicted in the Lukes-Collins model. A considerable proportion of mantle zone lymphocyte nuclear profiles had invaginations (ranging from 7.5% to 53.6%) and there was no difference between the frequency of deep indentations or clefts in mantle zone lymphocytes (8.1±5.4%) and the small unstimulated (9.3±5.3%) and partially transformed (8.4±1.4%) lymphocytes in follicular centers. Computer modeling of stylized nuclei with conical indentations indicated that all lymphocytic nuclei likely have multiple invaginations or groove-like creases.
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