Rheumatoid Factor-Associated High-Molecular-Weight Complexes in the Menstrual and Amniotic Fluids
作者:
Reuvit Halperin,
David Schneider,
Perry F. Kraicer,
Eran Hadas,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1996)
卷期:
Volume 41,
issue 3
页码: 220-223
ISSN:0378-7346
年代: 1996
DOI:10.1159/000292272
出版商: S. Karger AG
关键词: Rheumatoid factor;hDP200;Menstrual fluid;Amniotic fluid;High-molecular-weight complexes
数据来源: Karger
摘要:
We have previously described the identification of the human decidua-associated protein hDP200 as a rheumatoid factor [1], Assuming that rheumatoid factor binds to Fc of immunoglobulins, the existence of high-molecular-weight complexes was studie in decidual extract, pooled uterine fluid from proliferative and early secretory phase, menstrual fluid and amniotic fluid. High-molecular-weight complexes containing hDP200 and other immunoglobulins were found only in menstrual and amniotic fluids and not in decidual extract or uterine fluid. It is possible that complexing of the immunoglobulins by hDP200 serves as one of the mechanisms that ensure suppression of the immune response to fetal antigens.
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