Clinical-Pharmacological Investigation of Cyproterone Acetate
作者:
R.G.A. van Wayjen,
A. van den Ende,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1971)
卷期:
Volume 2,
issue 1-6
页码: 282-289
ISSN:0378-7346
年代: 1971
DOI:10.1159/000301868
出版商: S. Karger AG
关键词: Antiandrogenic hormones;Cyproterone acetate;Hirsutism;Balance studies
数据来源: Karger
摘要:
(1) The antiandrogenic steroid cyproterone acetate exerted a strongly negative nitrogen balance in 8 young male volunteers, the degree of which correlated with the dose administered. In a male patient of 77 years with cancer of the prostate, this catabolic effect proved to be much weaker. In 8 female patients with hirsutism, administration of cyproterone acetate resulted only then in a negative nitrogen balance when the food was deficient in calories and protein. Continuous treatment with cyproterone acetate in female patients is not feasible because of strongly progestational side-effects. These side effects can be avoided by combining cyproterone acetate with ethinyl estradiol as an ‘inverted sequential scheme’, according to Hammerstein and Cupceancy [2]. In most female patients with hirsutism, good or satisfactory results can be obtained by a continuous cyproterone acetate therapy or by the combination treatment of Hammerstein and CUPCEANCY [2].
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