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MinK-Related Peptide 1A &bgr; Subunit for the HCN Ion Channel Subunit Family Enhances Expression and Speeds Activation

 

作者: H.,   Yu J.,   Wu I.,   Potapova R.,   Wymore B.,   Holmes J.,   Zuckerman Z.,   Pan H.,   Wang W.,   Shi R.,   Robinson M.,   El-Maghrabi W.,   Benjamin J.,   Dixon D.,   McKinnon I.,   Cohen R.,  

 

期刊: Circulation Research: Journal of the American Heart Association  （OVID Available online 2001）
卷期: Volume 88, issue 12  

页码: 84-87

 

ISSN:0009-7330

 

年代: 2001

 

出版商: OVID

 

关键词: HCNfamily;MiRP1;KCNEfamily;&bgr;subunit

 

数据来源: OVID

 

摘要:

TheHCN family of ion channel subunits underlies the currentsIfin heart andIhandIqin thenervous system. In the present study, we demonstrate that minK-related peptide1 (MiRP1) is a &bgr; subunit for the HCN family. As such, it enhances proteinand current expression as well as accelerating the kinetics of activation.Because MiRP1 also functions as a &bgr; subunit for the cardiac delayedrectifierIKr,these results suggest that this peptide may have the unique role of regulatingboth the inward and outward channels that underlie cardiac pacemaker activity.The full text of this article is available athttp://www.circresaha.org.

 

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