Neuroblastoma (NB) is a tumor usually arising in children and young adults showing different degrees of malignancy. Recently, the presence ofN-mycamplification in neuroblasts has been associated with a poor outcome in the late stages of disease (Evans's Stage IV). Until now no amplification ofN-mycgene has been observed in Stage IV-S, usually considered to have a favorable prognosis. In this paper we report a case of a child affected by NB Stage IV-S showing mildN-mycgene amplification.The finding ofN-mycamplification in our patient shows that such alteration of theN-myconcogene is not necessarily correlated with a poor prognosis: in this light the role ofN-mycamplification in the neoplastic process should be reconsidered.