The Excretion of Caffeine in the Semen of Men: Pharmacokinetics and Comparison of the Concentrations in Blood and Semen
作者:
CYNTHIA A. BEACH,
JOSEPH R. BIANCHINE,
NICHOLAS GERBER,
期刊:
The Journal of Clinical Pharmacology
(WILEY Available online 1984)
卷期:
Volume 24,
issue 2‐3
页码: 120-126
ISSN:0091-2700
年代: 1984
DOI:10.1002/j.1552-4604.1984.tb02774.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract:The concentration of caffeine in the blood and semen of men was measured after an oral dose of 200 or 400 mg caffeine. Caffeine was rapidly absorbed (mean tmax= 0.76 ± 0.12 hour), with an average maximum concentration in the blood of 7.4 μg/ml for the 400‐mg dose and 3.4 μg/ml for the 200‐mg dose. The mean clearance of caffeine was 161 and 156 ml/min, while the mean volume of distribution was 50 and 47 liters for the 400‐ and 200‐mg doses, respectively. Distribution of caffeine into the semen was rapid, with a concentration of caffeine in the semen almost identical to that observed concurrently in the blood (blood/semen concentration ratio = 0.97). The mean half‐life of caffeine in the blood and semen was 3.7 and 3.6 hours, respectively, indicating that the decline of caffeine in the blood is very similar to that in semen. Thus, caffeine partitions rapidly into and out of the prostatic and seminal vesicular secretions, which contribute to the formation of t
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