Bilirubin Photooxidation Products in the Urine of Jaundiced Neonates Receiving Phototherapy
作者:
DAVID LIGHTNER,
WILLIAM LINNANE,
CHARLES AHLFORS,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 8
页码: 696-700
ISSN:0031-3998
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
Bilirubin-IXα photooxidation products were detected by high performance liquid chromatography in the urine of neonates undergoing phototherapy for hyperbilirubinemia. Thein vivophotoproducts were identified by chromatographic comparison with authentic synthetic standards using two complementary methods. Bilirubin photooxidation products were not detected in urine from jaundiced infants not receiving phototherapy. The specific photoproducts identified in the urine include propentdyopents, hematinic acid imide and its hydrolysis product (3-carboxy-2-methyl-2-hexenedioic acid), and the hydrolysis product (2-vinyl-3-methyl-maleic acid) of methylvinylmaleimide. Their total urinary concentrations were low (0.2–0.9 mg/dl) during phototherapy. These observations show that photooxidation of bilirubin clearly does occur during phototherapy. They are consistent with the view that, although photooxidation is not the major photochemical event associated with phototherapy, it can and clearly does occur concurrently with photoisomerization.
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