Simultaneous Determination of Adrenaline and Noradrenaline by First Derivative Spectrophotometry in a Fia Assembly
作者:
G.A. RIVAS,
S.Laredo ORTIZ,
J.Martínez Calatayud,
期刊:
Analytical Letters
(Taylor Available online 1996)
卷期:
Volume 29,
issue 12
页码: 2115-2124
ISSN:0003-2719
年代: 1996
DOI:10.1080/00032719608002235
出版商: Taylor & Francis Group
关键词: Derivative spectrophotometry;FIA;pharmaceutical analysis
数据来源: Taylor
摘要:
This article deals with the design of an unsegmented-flow injection manifold for the simultaneous determination of adrenaline and noradrenaline two structurally related compounds with overlapping spectra. An FIA manifold is proposed for the simultaneous determination in which the sample solution is directly injected into a carrier-reagent stream of aqueous NaOH. The selected wavelengths (first derivative) were 394 and 342 nm, for noradrenaline and adrenaline, respectively with an integration time of 0.4 s. The calibration graphs are linear over the range 2.0–30 ppm for both drugs. The method is applied to different synthetic mixtures of both drugs.
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