4‐substituted‐1,2,3,4‐tetrahydro‐3,3‐dimethylisoquinolines. II.
作者:
George Bobowski,
Jeffrey M. Gottlieb,
期刊:
Journal of Heterocyclic Chemistry
(WILEY Available online 1982)
卷期:
Volume 19,
issue 1
页码: 21-27
ISSN:0022-152X
年代: 1982
DOI:10.1002/jhet.5570190102
出版商: Wiley‐Blackwell
数据来源: WILEY
摘要:
AbstractA practical synthesis (Scheme I) is described for the preparation of a series of 4‐substituted‐3,3‐dimethyl‐1,2,3,4‐tetrahydroisoquinolines (3). Treatment of α‐(1‐amino‐1‐methylethyl)arylmethanols or α‐(1‐amino‐1‐methylethyl)heteroarylmethanols (5) with aromatic aldehydes gave imines7from which amino alcohols8were derived by reduction with potassium borohydride. Acid catalyzed cyclization of8yielded3. An acyl substituent was installed by Friedel‐Crafts acylation as a final step. The biological activities
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