SummaryMethicillin resistant staphylococci are often isolated in some hospitals (40 % of the strains).The study of minimal inhibitory concentration of Vancomycin, Gentamycin and Pristinamycin on multiresistant strains shows the good activityin vitrokept by the antibiotics. The pharmacological characteristics of Vancomycin make this antibiotic one of the best therapeutical agent against severe infection due to Methicillin resistant staphylococcus.