AbstractThe rate constants of hydrolysis of the enantiomers of amino acid nitrophenyl esters by catalytic domains composed of cationic surfactant aggregates and dipeptide catalysts orNdecanoyl‐L‐histidine have been determined at pH 7.30. The dipeptide catalysts shows large rate enhancement and stereoselectivity in aggregate domains. The surfactant structural effects are examined by investigation of the rate constants and stereoselectivities, and the nature of stereoselective catalysis is discus