Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?
作者:
ClassenH G,
SteinC,
ThöniH,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1990)
卷期:
Volume 9,
issue 5
页码: 500-502
ISSN:0731-5724
年代: 1990
DOI:10.1080/07315724.1990.10720407
出版商: Routledge
数据来源: Taylor
摘要:
Increasing doses of nitrite (3.7-14.8 mg/kg BW) were administered via intragastric intubation to 64 spontaneously hypertensive Sprague-Dawley rats. Systemic blood pressure, measured in conscious animals with the tail cuff method, significantly decreased in a dose-related manner 16 and 32 minutes later, and pulse rate slightly increased. Since orally ingested nitrate may be partially converted to nitrite, it seems worthwhile to study correlations between dietary nitrate and blood pressure in experimental animals and man.
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