The ignition of tetrahydrofuran (THF) has been studied in a single-pulse shock tube under reflected shock wave conditions while the oxidation of THF was studied in a high-pressure jetstirred reactor (JSR). The present experiments cover a wide range of conditions: 2–10atm, 0.5≤ ≤2.0, 800–1800K. The ignition delays of THF, measured in a shock tube, have been used to propose an overall representation for the dependence of ignition delay time on the concentration of each component in the ignitable gas mixture: τall=10-14.4exp (19590/T5)[c4h8O]0.272[O2-0.984[AR]-0.189(units:s, mole/dm3, K). Concentration profiles of the reactants, stable intermediates and products of the oxidation of ThF were measured in a JSR. A numerical model, consisting of a detailed kinetic reaction mechanism with 484 reactions (most of them reversible) of 71 species, describes the ignition of THF in reflected shock waves and its oxidation in a jet-stirred reactor. We observed a fairly good agreement between the experimental results and the computations. Detailed kinetic modeling enabled identification of the major reaction paths and sensitive kinetic parameters.