Analyses of Factors Contributing to Vulnerability to Antenatal Periventricular Leukomalacia Induced by Hemorrhagic Hypotension in Chronically Instrumented Fetal Sheep
作者:
TAKESHI KUSAKA,
TADASHI MATSUDA,
KAZUHIKO OKUYAMA,
KAZUTOSHI CHO,
SATORU OKAJIMA,
YOSHIYASU KOBAYASHI, AND,
SEIICHIRO FUJIMOTO,
期刊:
Pediatric Research
(OVID Available online 2002)
卷期:
Volume 51,
issue 1
页码: 20-24
ISSN:0031-3998
年代: 2002
出版商: OVID
数据来源: OVID
摘要:
Our purpose was to determine factors contributing to vulnerability to antenatal periventricular leukomalacia (PVL) induced by hemorrhagic hypotension in premature fetal sheep. Systemic hypotension was induced in 10 fetal sheep by acutely withdrawing 35% to 40% of the fetoplacental blood volume at 113 d gestation. Brains were processed for histologic analysis 6 d after the insult. Statistical comparisons of physiologic parameters between fetuses suffering from PVL (n= 5) and those without PVL (n= 5) were performed. Significant correlations were found between induction of PVL and fetal brain weight, changes in fetal mean blood pressure over time, base excess, oxygen content, hematocrit, and plasma arginine vasopressin (AVP) levels in fetal abdominal aortic blood. Brain developmental stage, the magnitude of induced systemic hypotension, and baseline blood oxygen content were important intrinsic factors in the induction of antenatal PVL by hemorrhagic hypotension in premature fetal sheep.
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