Optimal control in some cancer chemotherapy problems
作者:
GEORGEW. SWAN,
期刊:
International Journal of Systems Science
(Taylor Available online 1980)
卷期:
Volume 11,
issue 2
页码: 223-237
ISSN:0020-7721
年代: 1980
DOI:10.1080/00207728008967009
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
This paper deals with a number of ideas which may be applicable when investigating the use of modern optimal control theory to certain cancer chemotherapy problems. A new mathematical model is developed and incorporates the growth kinetics of the tumour together with a cell loss term involving the therapeutic agent. Then several new models with different performance criteria are discussed for populations of normal and tumour cells. The final section deals with a new control problem for a model having two compartments and a cell-cycle-specific chemotherapeutic agent.
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