Improvement of Anemia Among HIV-Infected Injection Drug Users Receiving Highly Active Antiretroviral Therapy
作者:
Richard Semba,
Nina Shah,
David Vlahov,
期刊:
JAIDS Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 2001)
卷期:
Volume 26,
issue 4
页码: 315-319
ISSN:1525-4135
年代: 2001
出版商: OVID
关键词: AIDS;Anemia;Chronic disease;Hemoglobin;HIV;Protease inhibitors
数据来源: OVID
摘要:
Although anemia is common during HIV infection, it is unclear whether potent antiretroviral therapy would improve or worsen anemia. We conducted a study to examine the impact of highly active antiretroviral therapy (HAART) on anemia in a cohort of HIV-positive injection drug users (IDUs) in Baltimore, Maryland. At baseline, the overall prevalence of anemia was 40%. During mean follow-up of one year, among 102 subjects who received HAART, there was a mean increase in hemoglobin of 3.6 ± 1.7 g/L (p= .04) and a mean decrease in log10plasma HIV load of 0.78 ± 0.17 copies/ml (p<.0001). Among 103 control subjects who were not receiving antiretroviral medications, there was a mean decrease in hemoglobin of 4.2 ± 1.1 g/L (p<.0003) and mean increase in log10plasma HIV load of 0.25 ± 0.06 copies/ml (p<.0002). Multivariate analysis using mixed linear models showed that HAART was associated with an increase of hemoglobin of 0.223 g/L per month (p<.0001) after adjusting for body mass index, opportunistic infections, and gender. HAART was associated with an improvement in anemia, and potential mechanisms that may be involved include a reduction in opportunistic infections and the anemia of chronic disease and an improvement in nutritional status.
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