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A novel cyclic GMP-lowering agent, LY83583, blocks carbachol-indiiced cyclic GMP elevation in rabbit atrial strips without blocking the negative inotropic effects of carbachol

 

作者: Jack Diamond,   Evelyn B. Chu,  

 

期刊: Canadian Journal of Physiology and Pharmacology  (NRC Available online 1985)
卷期: Volume 63, issue 8  

页码: 908-911

 

ISSN:0008-4212

 

年代: 1985

 

DOI:10.1139/y85-150

 

出版商: NRC Research Press

 

数据来源: NRC

 

摘要:

A novel cyclic GMP-lowering agent, LY83583(6-anilino-5,8-quinolinedkme), was used to investigate the possibility that increases in myocardial cyclic GMP levels are responsible for the negative inotropic effects of cholinergic agonists. Concentrations of carbachol from 0.3 to 3 μMelevated cyclic GMP levels in electrically paced rabbit atrial strips by 75 to 200% and decreased contractile force in the strips by 30 to 60%. Pretreatment of the muscles for 10 min with 10 μMLY83583 significantly lowered resting cyclic GMP levels and completely blocked the elevation of cyclic GMP by these concentrations of carbachol. However, the negative inotropic effects of carbachol were not blocked by the LY83583. These results indicate that the negative inotropic effects of carbachol in rabbit atrium are not mediated by increases in tissue levels of cyclic GMP.

 

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