Serum Melatonin after a Single Aqueous Subcutaneous Injection in Syrian Hamsters
作者:
George M. Vaughan,
Arthur D. Mason, Jr.,
Russel J. Reiter,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 2
页码: 124-127
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124262
出版商: S. Karger AG
关键词: Melatonin;Pineal;Hamster
数据来源: Karger
摘要:
A single injection of 25 µg melatonin was given subcutaneously in 0.1 ml saline either at 3 h into the light phase (morning) in female Syrian hamsters or at 1 h before the beginning of the dark phase (evening) in males (L/D 14/10 h). In both cases, the maximal mean serum values seen at 20 min after injection (50 ng/ml) were more than 1,000 times the normal nocturnal melatonin concentration. By 1 h after injection, serum melatonin had fallen to 10% (morning) or 4% (evening) of the respective 20-min value. The average half-times for plasma concentration during the second hour after injection were 14 min in the morning and 13 min in the evening. After either morning or evening injection, serum melatonin reached normal daytime concentration between 2 and 4 h after injection
点击下载:
PDF
(715KB)
返 回