The role of inflammation in the development of epiretinal membranes
作者:
HiscottP. S.,
UngerW. G.,
GriersonI.,
McLeodD.,
期刊:
Current Eye Research
(Taylor Available online 1988)
卷期:
Volume 7,
issue 9
页码: 877-892
ISSN:0271-3683
年代: 1988
DOI:10.3109/02713688808997245
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Single or multiple (3) injections of“Shigella”endotoxin were administered into the rabbit vitreous body to investigate the development of epiretinal membranes following intraocular inflammation. The evaluation included clinical assessment of the resulting traction retinal detachments, together with histological, autoradiographic, immunohistochemical and ultrastructural studies. Traction retinal detachments were found beneath fibroglial epiretinal membranes (being more extensive in eyes which had received 3 endotoxin injections) in the vicinity of the medullary rays, while purely glial membranes occurred over attached peripheral retina. The primary change at the vitreoretinal interface was an elevation of the inner limiting lamina of the retina followed by the extension of glial cells onto the retinal surface. It is postulated that glial cells breach the inner limiting lamina as a sequel to inflammation involving the vitreoretinal interface and form a scaffold upon which fibroblast-like cells migrate.
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