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Characterization ofFEN1gene involved in sensitivity to Sterol Biosynthesis Inhibitors inSaccharomyces cerevisiae

 

作者: Johann Joets,   Isabelle Soustre,   Rachida Kribii,   Didier Delourme,   Francis Karst,  

 

期刊: Acta Botanica Gallica  （Taylor Available online 1999）
卷期: Volume 146, issue 1  

页码: 67-72

 

ISSN:1253-8078

 

年代: 1999

 

DOI:10.1080/12538078.1999.10515802

 

出版商: Taylor & Francis Group

 

关键词: ergosterol;yeast;inhibitor;L-733,560;FEN1;YCR34W;GNS1;SUR5;SRE2;ELO2;ergostérol;levure;inhibiteur;L-733,560;FEN1;YCR34W;GNS1;SUR5;SRE2;ELO2

 

数据来源: Taylor

 

摘要:

The study of yeast sensitivity to sterols biosynthesis inhibitors led us to clone theFEN1gene. Strains carrying defective allele ofFEN1gene are resistant to inhibitors of post—squalene biosynthesis steps. Overexpression of this gene causes hypersensitivity to these inhibotors. Other groups have clonedFEN1gene in different physiological contexts. We present here the chromosomal localisation ofFEN 1at the YCR34W locus and results of investigations devoted to unterstand the function of this gene.

 

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