Relative Potencies of Human, Rat, Bovine/Caprine, Porcine and Ovine Hypothalamic Growth Hormone-Releasing Factors to Release Growth Hormone by the Rat Anterior Pituitary in vitro
作者:
Andrew Baird,
William B. Wehrenberg,
Nicholas Ling,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 4
页码: 273-276
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124451
出版商: S. Karger AG
关键词: Growth hormone;Growth hormone-releasing factor;Pituitary
数据来源: Karger
摘要:
Synthetic rat, human, bovine/caprine, porcine and ovine growth hormone-releasing factor (GRF) were tested for their capacity to release growth hormone (GH) by the rat anterior pituitary in vitro. All peptides elicited parallel and dose-dependent increases in GH release and produced similar maximal GH secretion. Rat GRF was 3–6 times more potent in stimulating the release of GH than all other GRFs, while human, bovine/caprine, porcine and ovine GRF had potencies that were not statistically different. The increased potency of both rat GRF(1–27)NH2 and rat GRF(1–23)NH2 when compared to human GRF(1–27)NH2 and human GRF(1–23)NGH2, respectively, suggests that the increased potency of this molecule resides in structural differences in the amino terminal of native GRF. The results demonstrate increased sensitivity of rat pituitary cells for their homologous releasi
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