Adhesion Molecules in Renal Diseases
作者:
MÜLlerGerhard A.,
MÜLlerClaudia A.,
MarkovicJasmina,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 5
页码: 711-724
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609047701
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Different adhesion molecules are implicated in the pathogenesis in glomerulonephritis. Leukocyte adhesion molecules play a critical role in causing renal damage in a variety of glome rulonephritic conditions. In order to understand the mechanisms by which distinct adhesion molecules are involved in human glomerulonephritis, it is necessary to have an overview of their function in maintenance of tissue architecture, morphogenesis, immunosurveillance, inflammation, tumor growth, etc. Thus, this review addresses the role ofcad-herins, selectins, integrins, and members of the immunoglobulin supergene family in developing, normal, and diseased kidney with special attention to glomerulonephritis and possible new therapeutic approaches.
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