Red blood cell damage by wollastonite:in vitrostudy
作者:
M. Aslam,
M. J. Arif,
Q. Rahman,
期刊:
Journal of Applied Toxicology
(WILEY Available online 1995)
卷期:
Volume 15,
issue 1
页码: 27-31
ISSN:0260-437X
年代: 1995
DOI:10.1002/jat.2550150107
出版商: John Wiley&Sons, Ltd.
关键词: red blood cells;wollastonite;chrysotile;haemolysis;lipid peroxidation;in vitro
数据来源: WILEY
摘要:
AbstractAsbestos is known to cause lung diseases in occupationally exposed workers. These properties have restricted its use. Industries have been exploring the possibility of other mineral fibres to replace the asbestos. In this direction, wollastonite has gained great attention owing to its high thermal resistance. In the present paper, the toxicity of three samples of Indian wollastonite was compared to that of chrysotile. Dust suspensions were added to the red blood cell suspensions to obtain a final dust concentration of 1.0–5.0 mg ml−1in the system. The wollastonite varieties were found to have smaller haemolytic potential in human red blood cells than that of chrysotilein vitro. Chrysotile also was more effective in inducting peroxidative damage of polyunsaturated fatty acid (PUFA) than wollastonites in the present system. The peroxidative damage of PUFA and the haemolysis were both time and dose dependent. A higher value of malonaldehyde (a lipid peroxidation product) formation in low‐speed supernatant of haemolysate was observed than in the intact cells. As the free‐radical scavengers vitamin E and reduced glutathione prevent haemolysis and lipid peroxidation, these data are consistent with the involvement of lipid peroxidation in the haemolytic
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