Increased Dosage of Carbidopa in Parkinsonian Patients on Low Carbidopa‐Levodopa RegimenEffect on Levodopa Bioavailability
作者:
Manuela Contin,
Roberto Riva,
Paolo Martinelli,
Gaetano Procaccianti,
Agostino Baruzzi,
期刊:
Clinical Neuropharmacology
(OVID Available online 1989)
卷期:
Volume 12,
issue 1
页码: 75-81
ISSN:0362-5664
年代: 1989
出版商: OVID
关键词: Carbidopa;Levodopa;Levodopa bioavailability;3-O-Methyldopa;Parkinson's disease
数据来源: OVID
摘要:
SummaryThe effect of a 2.5-fold increase in daily carbidopa intake on the bioavailability of levodopa was studied in six patients with Parkinson's disease on a low chronic regimen of carbidopa-levodopa (Sinemet) at the fixed ratio of 1:10. The extent of levodopa absorption, expressed as the area under the 11-h plasma levodopa concentration-time curve (AUC0–11 h), was not enhanced by the higher carbidopa dose. A significant increase in the AUC was found for the levodopa metabolite 3-O-methyldopa at the higher carbidopa intake. Clinical performances of individual patients were identical with both carbidopa-levodopa ratios. From these data, an adequate inhibition of peripheral decarboxylation and hence a good bioavailability of levodopa may be expected in patients taking low doses of carbidopa-levodopa, using currently available commercial preparations.
点击下载:
PDF
(379KB)
返 回