Characteristics of Lymphocyte Chromatin from Alzheimer’s Disease Patients and from Young and Old Normal Individuals
作者:
Timothy A.D. Smith,
Yvonne Vallis,
D. Neary,
Ruth F. Itzhaki,
期刊:
Gerontology
(Karger Available online 1989)
卷期:
Volume 35,
issue 5-6
页码: 268-274
ISSN:0304-324X
年代: 1989
DOI:10.1159/000213036
出版商: S. Karger AG
关键词: Chromatin;Lymphocytes;Micrococcal nuclease;Alzheimer’s disease
数据来源: Karger
摘要:
We have examined chromatin in lymphocytes from patients with Alzheimer’s disease (AD) and from normal individuals of a range of ages. We have found that the neucleosome repeat length does not vary with age for normal individuals over the range 24–78 years and that there is no difference between the value for AD cells (mean and standard deviation, 202 ± 7 base pairs, bp) and for normals (207 ± 5 bp). The rate of digestion of chromatin in lymphocyte nuclei by micrococcal nuclease does not appear to differ significantly between old and young normals and AD pat
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