Productive infection of T-helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4
作者:
Brian Willett,
Margaret Hosie,
Tom Dunsford,
James Neil,
Oswald Jarrett,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 12
页码: 1469-1475
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Feline immunodeficiency virus;T-helper cells;CD4
数据来源: OVID
摘要:
An antigen-specific feline T-lymphocyte cell line (Q201) was generated and infectedin vitrowith the feline immunodeficiency virus (FIV). Syncytium formation and the release of the viral core protein p24 into culture fluid were accompanied by a reduction in expression of the CD4 surface antigen. The reduction in CD4 expression was transient, the resulting persistently infected population of cells expressing levels of CD4 comparable to those observed prior to infection. Persistently infected cells gradually lost expression of major histocompatibility antigen (MHC) class II while maintaining pre-infection levels of expression of CD4, MHC class I, CD18 or CD29.
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