SummaryThe therapeutic use of fructose can be justified in two acute conditions : serious liver failure and diabetic coma.Other clinical applications will certainly be found but are not yet fully demonstrated.Fructose should be administered intravenously for it is converted to glucose in the intestinal wall after its ingestion. Even if its therapeutic usefulness is limited for the present time, the biochemical and physiologic observations it has yielded so far, are of great value.