Dose-Response Relation of CSF Sodium and Renal Sodium Excretion, and Its Absence in Homozygous Brattleboro Rats
作者:
David R. Mouw,
Arthur J. Vander,
Claudia Landis,
Sandra Kutschinski,
Nancy Mathias,
Deborah Zimmerman,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 30,
issue 4
页码: 206-212
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123002
出版商: S. Karger AG
关键词: Osmoreceptors;Vasopressin/antidiuretic hormone;Natriuresis;Cerebrospinal fluid
数据来源: Karger
摘要:
Constant intraventricular infusion (3.3–6.6 μl/min) of artificial cerebrospinal fluid with sodium concentrations of 100, 150, 200, 250, 300, and 350 mM produced a linear dose-related change in renal sodium excretion in conscious, unrestrained Sprague-Dawley rats. The periventricular receptors stimulated were able to evoke substantial changes in body sodium balance; the 350 mM Na CSF produced an estimated 14% deficit in the content of Na in the extracellular fluid over a 5-hour infusion period. This is the first demonstration of such a dose-response relation over a wide range of CSF Na concentration (above and below normal) in conscious animals. Both the dose-response relation, and the magnitude of the effects, suggests an important physiologic role for this control mechanism. The natriuresis in response to 300 mM sodium infusion was identical in Long-Evans Brattleboro rats heterozygous for diabetes inspidus (Dl), and in Sprague-Dawley rats, but was completely absent in homozygous animals. Although the experimental methods (conscious unrestrained rats) precluded simultaneous evaluation of efferent pathways other than antidiuretic hormone (ADH), the evidence from the DI rats suggests that ADH may be the efferent pathway for the respon
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