Late‐Life Depression as a Possible Predictor of DementiaCross‐Sectional and Short‐Term Follow‐Up Results
作者:
Robert van Reekum,
Martine Simard,
Diana Clarke,
Malcolm Binns,
David Conn,
期刊:
American Journal of Geriatric Psychiatry
(OVID Available online 1999)
卷期:
Volume 7,
issue 2
页码: 151-159
ISSN:1064-7481
年代: 1999
出版商: OVID
关键词: Depression;Alzheimer's Disease;Prediction
数据来源: OVID
摘要:
The authors explored cognitive functioning of a group of elderly subjects with depression. The group as a whole, and, in particular, the late-onset group (LOD), demonstrated cognitive impairment on the Mattis Dementia Rating Scale (MDRS). Subgroup differences were significant at P=0.004. This between-group difference was not seen when age and level of education were controlled. In the LOD group, 47.5% (vs. 31.5% of the early-onset group [P=0.025]), scored below the cutoff for dementia. Age-at-onset status in a logistic regression model predicted MDRS category, and treatment of the depression had little effect on cognition. Results support the hypothesis that late-life depression, particularly LOD, is associated with cognitive impairment that may represent early AD.
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