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Potent Inhibition of Neuraminidase By N-(1,2-Dihydroxypropyl) Derivatives of Siastatin B and Its Analogs

 

作者: Yoshio Nishimura,   Toshiaki Kudo,   Yoji Umezawa,   Shinichi Kondo,   Tomio Takeuchi,  

 

期刊: Natural Product Letters  （Taylor Available online 1992）
卷期: Volume 1, issue 1  

页码: 33-38

 

ISSN:1057-5634

 

年代: 1992

 

DOI:10.1080/10575639208048883

 

出版商: Taylor & Francis Group

 

关键词: N-(1,2-Dihydroxypropyl)siastatin B;N-(1,2-Dihydroxypropyl)-4-ene-siastatin B;N-(1,2-Dihydroxypropyl)-4-deoxysiastatin B;N-(1,2-Dihydroxypropyl)-4,5-di-epi-siastatin B;Neuraminidase;Oxocarbenium ion of neuraminic acid

 

数据来源: Taylor

 

摘要:

Inhibitors, reaction intermediates and substrate analogs of neuramic acid were studied by molecular graphics. Based on this chemically modified analogs of siastatin B, an inhibitor of neuraminidases were synthesized. the results indicated that potent inhibitors must be good topographical analogs of the oxocarbenium ion of neuraminic acid, an intermediate in the reaction catalyzed by neuraminidase.

 

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