Haptoglobin Phenotypes in Diabetes mellitus and Diabetic Retinopathy
作者:
Tanuja Chandra,
C.N. Lakshmi,
T. Padma,
M. Vidyavathi,
M. Satapathy,
期刊:
Human Heredity
(Karger Available online 1991)
卷期:
Volume 41,
issue 5
页码: 347-350
ISSN:0001-5652
年代: 1991
DOI:10.1159/000154023
出版商: S. Karger AG
关键词: Diabetes mellitus;Diabetic retinopathy;Haptoglobin types
数据来源: Karger
摘要:
An analysis of haptoglobin (HP) phenotypes in 81 cases of diabetes mellitus (DM) without retinopathy and 122 cases with diabetic retinopathy (DR) were studied in relation to 180 normal and healthy controls matched for age and sex. A significant decrease in HP 2–1 frequency was found, suggesting protection for heterozygotes in both DM and DR (with a relative risk of about 0.31). As an acute-phase reactant HP may be functionally involved in the etiology of DM and DR, which are associated with immunologic and inflammatory processes, respectively. No significant differences were found with respect to sex, age at onset, duration of DR, types of DM and DR, and family histor
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