Adenoma‐Carcinoma Sequence of ColorectumPrevalence of K-rasGene Mutation in Adenomas with Increasing Degree of Dysplasia and Aneuploidy
作者:
Renzo Ranaldi,
Anna Gioacchini,
Aldo Manzin,
Massimo Clementi,
Stefania Paolucci,
Italo Bearzi,
期刊:
Diagnostic Molecular Pathology
(OVID Available online 1995)
卷期:
Volume 4,
issue 3
页码: 198-202
ISSN:1052-9551
年代: 1995
出版商: OVID
关键词: Colorectal adenomas;Colorectal carcinoma;K-rasmutation;Aneuploidy.
数据来源: OVID
摘要:
One hundred and fifty colorectal adenomas were investigated in order to detect the presence of K-rasgene mutation. The adenomas were classified according to the severity of the histological lesion (mild, moderate, or severe dysplasia and carcinomatous transformation) and to the degree of aneuploidy. K-rasmutation was found in 30.8% of cases, mostly consisting of a point mutation of codon 12. K-rasmutation was more frequently found in adenomas >1 cm and in the villous type. No correlation was otherwise demonstrable with the ploidy pattern of the lesion.
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