ObjectiveThe objective of this case series was to determine if severe phantom limb pain could be reduced with oral methadone.DesignFour cases of phantom limb pain refractory to multiple treatment modalities were treated with oral methadone.SettingPain clinic at a major university medical center.PatientsFour patients with severe, intractable phantom limb pain.InterventionOral methadone was administered, starting with a low dose of 2 to 5 mg twice a day or three times a day and slowly titrated upward to achieve pain relief.Outcome MeasuresRepeated administration of a visual analog scale for pain.Results and ConclusionsAdministration of oral methadone may be of value in the treatment of phantom limb pain; controlled clinical trials would be appropriate to verify this observation.