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Influence of sarcosine orN‐methylalanine in position 7 on the antagonistic properties of [1‐deaminopenicillamine]‐ and [1‐(β‐mercapto‐β, β‐cyclopentylmethylene‐propionic acid)]‐vasopressin

 

作者: Diana Gazis,   Irving L. Schwartz,   B. Lammek,   Zbigniew Grzonka,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1984）
卷期: Volume 23, issue 1  

页码: 78-83

 

ISSN:0367-8377

 

年代: 1984

 

DOI:10.1111/j.1399-3011.1984.tb02695.x

 

出版商: Blackwell Publishing Ltd

 

关键词: AVP analogs;inhibitors;N‐methylalanine;penicillamine;sarcosine

 

数据来源: WILEY

 

摘要:

Substituting sarcosine orN‐methylalanine for proline in the inhibitory vasopressin analogs dPAVP and d(CH2)5AVP had the following effects: 1) milk ejection and antidiuretic activities were severely depressed, 2) pressor antagonism was maintained but weakened somewhat, and 3) antagonism in the uterusin vitrowas maintained, but no consistent pattern was see

 

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