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Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats

 

作者: M. P. Servé,   B. M. Llewelyn,   K. O. Yu,   G. M. McDonald,   C. T. Olson,   D. W. Hobson,  

 

期刊: Journal of Toxicology and Environmental Health  （Taylor Available online 1989）
卷期: Volume 26, issue 3  

页码: 267-275

 

ISSN:0098-4108

 

年代: 1989

 

DOI:10.1080/15287398909531253

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1‐tetralol, 2‐tetralol, 2‐hydroxyl‐1‐tetralone, 4‐hydroxyl‐1‐tetralone, 1,2‐tetralindiol, and 1,4‐tetralindiol. Rats treated with tetralin demonstrated the classic lesions of hydrocarbon‐induced nephropathy.

 

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