Background: Communications concerning Hodgkin’s disease (HD) after non-Hodgkin’s lymphoma (NHL) are rather rare, whereas NHL after HD represents a common form of dual lymphoma. Patient: A 68-year-old woman developed nodular sclerosing HD of the upper mediastinum and right supracla-vicular fossa stage ΠB 2 years after splenectomy for a splenic lymphoplasmocytoid immunocytoma. She died of septic infection after 2 cycles of COPP-ABVD and a thoracic mantle field radiation during extended field radiation of paraaortic lymph nodes. Conclusion: If new lymph node enlargements occur during long-time management of patients with malignant lymphoma, repeated histologie investigations are imperative in order to separate between relapse, transformation or a dual lymphoma. Concordant with current literature we assume that patients with NHL are at an increased risk to have HD. They are almost twice as old as patients with primary HD, mostly have a nodular sclerosing histology and a poor prognosis. The development of HD as a secondary lymphoma is mainly due to unbalanced immune competence and not to precedent cytotoxic the