Statistical modelling in analysis of prognosis in glioblastoma multiforme: A study of clinical variables and Ki-67 index
作者:
PigottTimothy J. D.,
LoweJames S.,
PalmerJanet,
期刊:
British Journal of Neurosurgery
(Taylor Available online 1991)
卷期:
Volume 5,
issue 1
页码: 61-66
ISSN:0268-8697
年代: 1991
DOI:10.3109/02688699108998448
出版商: Taylor&Francis
关键词: Glioblastoma multiforme;Ki-67;prognosis
数据来源: Taylor
摘要:
Statistical modelling was used to analyse clinical features and the Ki-67 proliferation index in a study of 77 cases of glioblastoma multiforme. Relative youth, frontal tumour site and treatment with external beam radiation had an important positive influence on survival. The pre-operative Karnovsky score and the presence of necrosis were not related to outcome. Despite the attractive hypothesis that rapidly proliferating tumours might be associated with a worse prognosis compared with slowly proliferating lesions, the Ki-67 index in this study offered no prognostic information even when individual sites were considered separately. The use of this form of computer modelling and its role in analysis of prognostic data is discussed.
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