Lactate Uptake and Metabolism by Brain During Hyperlactatemia and Hypoglycemia
作者:
EDWIN,
NEMOTO JULIAN,
HOFF JOHN,
期刊:
Stroke
(OVID Available online 1974)
卷期:
Volume 5,
issue 1
页码: 48-53
ISSN:0039-2499
年代: 1974
出版商: OVID
关键词: cerebrospinal fluid;glucose;cerebral blood flow;lactacidemia;blood-brain barrier
数据来源: OVID
摘要:
Entry into CSF and consumption by brain of blood-borne lactate (La) was quantified in pentobarbital-anesthetized, normocapnic dogs loaded and infused with NaLa and HLa to hold constant, in arterial blood, both the La concentration at about 8 mM (normal = 1 mM) and the pH at 7.4. In four dogs studied hourly over six hours, the arteriosagittal sinus blood concentration difference (δA-V La) was 0.41 ± 0.14 (SE) mM (P <0.05) and was time independent. CSF La rose slowly over four hours to about 0.6 of blood La while cisternal CSF pH remained nearly constant. Four acetate loaded controls showed no changes of δA-V La, CSF La, CSF, or arterial pH. Brain uptake of La was quantitated in eight dogs during insulin-induced hypoglycemia, to minimize possible competition by glucose. Cerebral blood flow (CBF) and δA-V for La, glucose, and O2were determined at 30-minute intervals. CBF and cerebral metabolic rate of O2(CMRO2) both fell about 17% during two hours of hypoglycemia and returned to control with La loading although blood glucose continued to fall to 1.5 mM. In the two hour La loaded period δA-V La was 0.27 ± 0.10 mM (n = 32) and CSF La rose to 0.7 of arterial La without altering CSF pH. CMRO2averaged 1.61 ± 0.14 μ mol/(min.gm brain), of which CMR glucose (×6 to give O2, equivalents) provided 75% or 1.18 ± 0.13 μ O2eq/(min.gm). CMR La × 3 was 28% of CMRO2or 0.45 ± 0.15 μ eq/(min.gm). The results suggest that blood-borne La can stoichiometrically replace about one-fourth of the glucose used as brain substrate during hypoglycemia, and probably during normoglycemia. Uptake may be limited by saturation of carriers facilitating passage of La across the blood-brain barrier and into brain cells.
点击下载:
PDF
(234KB)
返 回