Endogenous nitric oxide modulates naloxone-precipitated withdrawal signs in a mouse model with acute cholestasis
作者:
A R Dehpour,
N Akbarloo,
P Ghafourifar,
期刊:
Behavioural Pharmacology
(OVID Available online 1998)
卷期:
Volume 9,
issue 1
页码: 77-80
ISSN:0955-8810
年代: 1998
出版商: OVID
关键词: bile duct resection;cholestasis;mice;naloxone;nitric oxide;opioid;withdrawal signs
数据来源: OVID
摘要:
Cholestasis liver disease is associated with clinical and experimental findings consistent with increased opioidergic neuromodulation, increased plasma total activity, and elevated plasma enkephalin concentrations. The effect of the nitric oxide (NO) synthase inhibitor, L-nitro-arginine (L-NA, 0.03, 0.1, 0.3, 1 mg/kg), and the nitric oxide precursor, L-Arg (30 mg/kg), on antinociception induced by bile duct resection or sham operation, as well as on opioid dependence, was examined in male albino Swiss mice. Repeated (5 days) administration of L-NA attenuated signs of dependence, as assessed by naloxone (5 mg/kg)-precipitated withdrawal, and decreased the antinociception; however, L-Arg potentiated withdrawal signs and increased the antinociception. The results of this study support the involvement of the L-arginine/nitric oxide pathway in the opioidergic-dependent manifestation of cholestasis in an animal model.
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