This review of self-care focuses on key theorists and their models, relevant research findings, and interventions that create changes in the cognitive, behavioral, and physical well-being of individuals. The article also provides a review of the theory underlying self-care and the influence of related disciplines on the concept. After a discussion of potential barriers, the determinants of these health-promoting behaviors are addressed. The review of stress focuses almost exclusively on studies that suggest helpful coping mechanisms for nurses in the workplace. Key variables addressed include the hardiness dimension and the organizational climate necessary for a supportive workplace.