Homocystinuria and SchizophreniaLiterature Review and Case Report
作者:
PATRICK BRACKEN,
PATRICK COLL,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1985)
卷期:
Volume 173,
issue 1
页码: 51-55
ISSN:0022-3018
年代: 1985
出版商: OVID
数据来源: OVID
摘要:
The autosomal recessive disorder homocystinuria involves, in all its subgroups, an abnormality of methionine metabolism. The metabolism of methionine has been a central focus of interest for those who propose the transmethylation hypothesis of schizophrenia. The “methionine effect,” as described in the research literature, is thus a theoretical link between these two disorders. The authors review the literature and describe those cases where both have occurred in the same patient. They indicate that whereas many patients with homocystinuria have been psychotic, few have been actually labeled schizophrenic. A patient with homocystinuria, mental retardation, and episodic psychosis is described and this case is used to point to the difficulties in making a definite psychiatric diagnosis in these patients. A relationship between the two syndromes is suggested.
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