Nature of lectin‐induced alteration of potassium transfer in Ehrlich ascites tumor cells
作者:
Felice Aull,
Martin S. Nachbar,
Joel D. Oppenheim,
期刊:
Journal of Cellular Physiology
(WILEY Available online 1977)
卷期:
Volume 90,
issue 1
页码: 9-14
ISSN:0021-9541
年代: 1977
DOI:10.1002/jcp.1040900103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe way in which the lectins concanavalin A (Con A) andRicinus communisagglutinin (Ricin) alter the K+content of Ehrlich ascites tumor cells was investigated. Unidirectional and net fluxes were determined in unwashed cells during a time course following lectin addition. Total influx, ouabain sensitive influx, Mg++‐ and Na+‐K+‐ATPase activity were all unaffected. Cell ATP content was normal for at least 19 minutes after exposure to Con A. Early after contact with Ricin or Con A efflux was stimulated 2‐3‐fold, resulting in net K+loss, but after 20 minutes efflux had returned to normal. Ricin and Con A acted similarly although Ricin was present at only 1/50 the concentration of Con A. When the findings are evaluated together with previous work it is suggested that a particular membrane glycoprotein may be concerned in the efflux alteration
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