Statistical resolution of genetic heterogeneity in familial disease
作者:
CHARLES SMITH,
期刊:
Annals of Human Genetics
(WILEY Available online 1976)
卷期:
Volume 39,
issue 3
页码: 281-291
ISSN:0003-4800
年代: 1976
DOI:10.1111/j.1469-1809.1976.tb00132.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SummaryIf a disease can be split into two or more groups on any criterion (clinical, biochemical, physiological or statistical) then the grouping can be tested to establish if genetically independent forms of the disease have been identified. The data required are simply the frequencies of the two disease groups in relatives of probands for each of the disease groups. A systematic search for such distinct groups is proposed in searches for genetic heterogeneity in familial diseases.
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