Murine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man
作者:
BrilliantMurray H.,
NiemannMark M.,
EicherEva M.,
期刊:
Journal of Neurogenetics
(Taylor Available online 1987)
卷期:
Volume 4,
issue 3
页码: 259-266
ISSN:0167-7063
年代: 1987
DOI:10.3109/01677068709167186
出版商: Taylor&Francis
关键词: Tyrosine hydroxylase;Gene mapping;Recombinant inbred mouse strain;Conserved linkage
数据来源: Taylor
摘要:
The locus of the structural gene encoding tyrosine hydroxylase,Th, the rate limiting enzyme for catecholamine biosynthesis, was mapped to the distal end of mouse Chromosome (Chr) 7. A DNA probe of genomic origin of rat tyrosine hydroxylase was used to detect restriction fragment length variants among 8 inbred mouse strains. The strain distribution pattern ofThallelic variants in 3 sets of recombinant inbred mouse strains was determined. Comparison of the strain distribution patterns ofThalleles with those of previously typed loci suggestedThwas located on Chr 7. The Chr 7 assignment forThwas confirmed by analyzing 108 mice produced from an (NZB×SM)F1×NZB backcross. Moreover, theThlocus was positioned distally on Chr 7. Mouse Chr 7 and human Chr 11p (the location of the human tyrosine hydroxylase gene) are known to share several homologous loci. With the addition ofTh, the homology between the distal 2/3 of mouse Chr 7 and human Chr 11p appears extensive.
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