Successful chemotherapy for childhood metastatic embryonal cell carcinoma of the testicle: A preliminary report
作者:
C. Tate Holbrook,
William M. Crist,
Walter Cain,
Anton Bueschen,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1980)
卷期:
Volume 8,
issue 1
页码: 75-81
ISSN:0098-1532
年代: 1980
DOI:10.1002/mpo.2950080111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: testicular tumors;embryonal cell carcinoma;chemotherapy;metastatic involvement;cis‐diamminedichloroplatinum;alpha‐fetoprotein
数据来源: WILEY
摘要:
AbstractA child with widespread metastases successfully treated with chemotherapy alone is described. One course of combination chemotherapy using cis‐platinum, vinblastine, and bleomycin produced disappearance of multiple pulmonary metastatic lesions. Four courses of therapy produced shrinkage and tumor sterilization of an abdominal mass. Twenty‐six months after initiation of chemotherapy the patient is well, off of all therapy for fourteen months, and free of disease or drug related complication with normal creatinine clearance and alpha‐fetoprotein determinations.The published adult experience demonstrates that this therapy is extremely effective for the treatment of metastatic embryonal cell carcinoma of the testis in young adults, and our case report extends this favorable experience into childhood. Toxicity is substantial, but justifiable considering the poor outlook associated with widespread metastatic disease. Collectively, the reviewed data suggest that further trials of this type of therapy are indicated in chi
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