In vitro Glucoregulation of Prolactin Secretion
作者:
Carol Langford,
Junko Kadowaki,
Ameae M. Walker,
期刊:
Neuroendocrinology
(Karger Available online 1992)
卷期:
Volume 56,
issue 6
页码: 838-844
ISSN:0028-3835
年代: 1992
DOI:10.1159/000126314
出版商: S. Karger AG
关键词: Prolactin;Glucoregulation;Insulin
数据来源: Karger
摘要:
In this study we have examined the direct glucoregulation of prolactin secretion from normal anterior pituitary cells in vitro and have found that changes in medium glucose concentration regulate the amount of prolactin released. Nature and/or degree of this response to glucose was influenced by some effect, long-lived in vitro, which was correlatable to serum insulin levels. When the cells were derived from animals with mean low-normal serum insulin levels, there was a stimulation of prolactin secretion by hypoglycemia, the response was rapid, transient, dose-dependent, and could be duplicated by 2-deoxyglucose. When the cells were derived from animals with a higher mean serum insulin level, the prolactin secretion from the cells was slowly, adversely affected by hypoglycemia. Conversely, elevated glucose caused a depression in prolactin secretion in the first group and a stimulation of prolactin secretion in the second. We conclude (1) that modulation of glucose levels in vitro regulates prolactin release from pituitary mammotrophs and (2) that this glucose regulation of prolactin release is in turn coregulated with or regulated by insulin.
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