Impairment of Cerebral Blood Flow Autoregulation in the Newborn Lamb by Hypoxia
作者:
ARNOLD TWEED,
JACQUES COTE,
HANS LOU,
GEORGE GREGORY,
JOHN WADE,
期刊:
Pediatric Research
(OVID Available online 1986)
卷期:
Volume 20,
issue 6
页码: 516-519
ISSN:0031-3998
年代: 1986
出版商: OVID
关键词: CBF, cerebral blood flow;MABP, mean arterial blood pressure;IAI, index of autoregulatory impairment
数据来源: OVID
摘要:
Autoregulation of cerebral blood flow has been demonstrated in both fetal and newborn animal models under normoxic conditions. In the present experiments we have attempted to define the minimal hypoxic insult which impairs autoregulation in the newborn Iamb and to assess the time to recovery. We measured cerebral blood flow by the intracarotid133Xe method in fifteen 4- to 9-day-old lambs and tested autoregulation of cerebral blood flow by increasing blood pressure 20-30% with phenylephrine. Autoregulation was tested in the control state and at successive time intervals after an hypoxic stress (Pao2of 30 mm Hg) of 10 or 20 min. We found that cerebral autoregulation was abolished after 20 min of hypoxia and recovered within 7 h. Since this model identifies the minimal hypoxic insult to abolish autoregulation it might be used to study means to protect autoregulation or to hasten its recovery after hypoxia. (Pediatr Res 20:516-519,1986)
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